Abstract
Objective: In order to make the wide use of the accumulated data for the development of HIV/AIDS vaccines, we developed the HIV Infectious Diseases Integrated Database (HIV-DB; URL=https://aids.nih.go.jp) and made it available to any HIV-related researchers via Internet.
Outline: The HIV-DB provides virological and genetic data, such as results of virus isolation, nucleotide sequences information on HIV-1 and structural information on the virus proteins, integrated with indispensable clinical data, which have been collected and analyzed at the National Institute of Infectious Diseases (NIID) since 1988.
Contents: The HIV-DB includes the HIV DNA database of the DNA Databank of Japan (DDBJ), results of virus isolation (n=3, 217), C2V3 DNA data (n=361), V3 loop structural data (PDB format, n=269), and corresponding clinical data (birth year, sex, CD4 lymphocyte count, plasma virus lord, drug history, etc.), which have been obtained from 572 HIV-1-infected individuals in Japan. Several functions including FASTA similarity search analysis against the HIV DNA database of DDBJ, phylogenetic tree analysis, genosubtyping of HIV-1, creation of individual user divisions, browsing 3D view of V3 loop structure and search for corresponding clinical data, are also available on the WEB site.
Remarks: The HIV-DB was developed by collaboration of NIID and the Japan Science and Technology Corporation.
