Development of regenerative technology applying mechanical stress on tissue formation and organogenesis

Abstract

Physical stimuli (mechanical stress) are involved in the biological functions such as cell proliferation, differentiation, and morphogenesis, and have been developed as mechanobiology to elucidate their mechanisms. In the field of regenerative medicine, many researchers investigate the biological effects of mechanical stress and mechanical environments. In recent years, novel regenerative technologies have been developed to regulate the morphogenesis of bioengineered organs and to activate the maturation of regenerated tissues without the use of differentiation-inducing factors. This paper describes the effects and applications of mechanical stresses, such as external pressure and occlusal stimulation, on tooth organogenesis and maturation of periodontal tissues.