Abstract
We report a case that was successfully treated invasive pulmonary aspergillosis after living donor lobar lung transplantation
and monitored patients' immune function with ImmuKnow® assay. A 43-year-old woman underwent living donor lobar lung
transplantation for pulmonary alveolar proteinosis. Two healthy her relatives donated each lower lobe. Six months after transplantation,
she was diagnosed as invasive pulmonary aspergillosis (IPA). During the anti-fungal treatment, one immunosuppressant
was withdrawn and the trough level of calcineurin inhibitor was reduced to the minimum. Despite of such a low
immunosuppressive status, Immuknow® assay showed that immune function was maintained in the moderate range, which
encouraged us to keep this strategy for IPA. Immune evaluation by Immuknow® is useful method for monitoring and controlling
patients' immune status especially in the infected condition, which revealed moderate immune level could be maintained with
only two immunosuppressant drugs in the patient after recovery from IPA.
