Crystal Structure and Synthesis of 1-Benzyl-4-(5,6-dimethoxy-1H-2-indenylmethyl)piperidine, a Donapezil Impurity

Abstract

The crystal structure of 1-benzyl-4-(5,6-dimethoxy-1H-2-indenylmethyl)piperidine, C₂₄H₂₉O₂N, has been determined. The compound crystallizes from methanol solvent in the monoclinic system, space group P2₁ with the following unit-cell parameters: a=10.245(8), b=5.523(4), c=18.670(2)Å, β=102.472(7)°, Z=2, V=1031.5(16)ų. The crystal structure was solved by direct methods and refined by full-matrix least squares to a final R-value of 0.050 with 3751 unique reflections.