Synthesis and Crystal Structure of 2-(4-Methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

Abstract

A new dipolarophile, used to construct bioactive heterocycles, 2-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-acrylonitrile, C₁₉H₁₉NO₄, was synthesized by base-catalyzed reaction of 3,4,5-trimethoxybenzaldehyde with (4-methoxyphenyl)acetonitrile. The compound crystallizes in the monoclinic space group P2₁/c with cell parameters a = 7.2880(4)Å, b = 8.1030(9)Å, c = 28.460(3)Å, β = 94.018(5)°, Z = 4. The structure exhibits both inter and intramolecular hydrogen bonds of the type C-H…O and C-H…N.