Crystal Structure of a 2:1 Complex of Indomethacin and Lidocaine

Yukiko UMEDA; Hiromasa NAGASE; Mizue MAKIMURA; Kazuo TOMONO; Motoo SHIRO; Haruhisa UEDA

doi:10.2116/analscix.23.x15

Analytical Sciences: X-ray Structure Analysis Online

Online ISSN : 1348-2238
ISSN-L : 1348-2238

Part 1

Crystal Structure of a 2:1 Complex of Indomethacin and Lidocaine

Yukiko UMEDA, Hiromasa NAGASE, Mizue MAKIMURA, Kazuo TOMONO, Motoo SHIRO, Haruhisa UEDA

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JOURNAL FREE ACCESS

2007 Volume 23 Pages x15-x16

DOI https://doi.org/10.2116/analscix.23.x15

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Abstract

Crystals of a 2:1 complex, (C_l9H₁₆ClNO₄)₂·C₁₄H₂₂N₂O, between indomethacin and lidocaine were grown by slow evaporation from an ethanol solution. Two different indomethacin (I and II) molecules showed different conformations. The proton of the carboxyl group of indomethacin II was transferred to an amino group of lidocaine. The intermolecular hydrogen bonds and CH/π interactions were observed.

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