Annals of Nuclear Cardiology
Online ISSN : 2424-1741
Print ISSN : 2189-3926
ISSN-L : 2189-3926
Which PET Flow Tracer Is the Best for MBF Quantification?
15O-labeled Water is the Best Myocardial Blood Flow Tracer for Precise MBF Quantification
Osamu ManabeMasanao NayaTadao AikawaKeiichiro Yoshinaga
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2019 Volume 5 Issue 1 Pages 69-72


Oxygen-15-labeled water (15O-H2O) is used as a radiopharmaceutical tracer with positron emission tomography (PET). Its short radioactive half-life permits consecutive rest and stress imaging acquisition while requiring an on-site cyclotron near a PET imaging system. 15O-H2O PET has the disadvantage of being less than ideal for visual assessment; however, its high extraction fraction allows for highly accurate quantification of myocardial blood flow (MBF). Therefore, 15O-H2O is considered to be a gold standard for MBF quantification. This is one of the great advantages of 15O-H2O PET over other PET myocardial perfusion imaging modalities. The purpose of this review is to provide the advantages and characteristics of 15O-H2O PET.

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© The Japanese Society of Nuclear Cardiology 2019
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