Investigation of intervention effect on stress response abnormality in low birth weight rats

Abstract

Corticotropin releasing factor (CRF) is released not only in the anterior pituitary but also in the amygdala, the locus ceruleus and the lateral nucleus of the medulla oblongata, and has various physiological actions such as the endocrine system of stress response and autonomic nerve regulation. We found that restraint-induced elevation of corticosterone levels in the blood were elongated in low birth weight rats from dams fed a low sugar and calorie restricted diet during pregnancy, and that blood Methionine has decreased in low birth weight rats compared to control rats. Feeding the methyl modulator diet to lactating dams normalized the restraint-induced elevation of blood corticosterone concentration. Therefore, in this mini-review, the effect of early intervention by methyl modulator will be outlined.