Autonomic dysfunction in patients with REM sleep behavior disorder

Abstract

Patients with REM sleep behavior disorder (RBD）had subjective symptoms of autonomic dysfunction compared with normal healthy controls. Scores of autonomic dysfunctions in patients with RBD were similar to those in patients with Parkinson’s disease (PD). Objectively, patients with RBD had orthostatic hypotension and abnormal heart rate variability similar to PD. Also, patients with RBD had similar degree of reduced uptake of MIBG scintigrams to those with PD. Subjective and objective intestinal dysfunction in patients with RBD is reported. The pathological lesion of RBD are thought as locus coeruleus that are associated with control of autonomic function. It is expected whether autonomic dysfunction in patients with RBD is predictive symptoms because it is paid attention to develop synuceinopathies in patients with RBD.