Proposal of pre-borderline neuropathy as a new disease entity and construction of novel ultra-early diagnosis methods for detecting the disease

Abstract

It is well known that impaired glucose tolerance neuropathy is characterized by early selective involvement of small nerve fibers. We adopted compound method （laser-Doppler flowmetry and urinary myoinositol measurement） for detecting the onset of small-fiber neuropathy in impaired glucose tolerance. Moreover, we also found the existence of “pre-borderline neuropathy”. We are currently working on elucidating its pathogenesis and devising a very early diagnosis method.