Relationship between gut bacteria and metabolites in neurological diseases

Abstract

Recently, there have been many reports on the involvement of intestinal bacteria in the pathogenesis of neurological diseases. In particular, many reports have been made in multiple sclerosis, which is considered a representative immune disease, and Parkinson’s disease, which is a neurodegenerative disease. In the small intestine, intestinal bacteria are scarce and mostly aerobic, but in the large intestine, there are nearly 100 trillion bacteria, and their roles are very different. In this paper, we will review the roles of these two intestinal bacteria, including our research on Parkinson’s disease.