Translational research based on functional mechanisms of Kampo medicine

Abstract

Major depressive disorder (MDD) is one of the leading causes of disturbances in emotional, cognitive, autonomic, and endocrine functions, according to the large amount of information on MDD that has been accumulated during recent years. Although dysregulation of the HPA axis by chronic stress is indicative of MDD, the molecular mechanisms and functional changes in the brain underlying depression are largely unknown. Yokukansan (YKS) can affect behavioral and psychological symptoms such as aggression, anxiety, and depression in patients with Alzheimer's disease and other forms of dementia, and Kamishoyosan (KSS) is widely used for the treatment of various neuropsychiatric symptoms in perimenopausal and postmenopausal women. In the previous study, we developed specific animal models and indicated molecular mechanisms of the YKS and KSS functions for these various neuropsychiatric symptoms. These results suggest that one or more active ingredients in YKS and KSS could be used as a possible alternative to current antidepressant drugs.