2025 Volume 62 Issue 1 Pages 32-38
The physical and psychological symptoms of 35 healthy subjects, ranging in age from 21 to 62 years (mean age, 42 years), were assessed using the pupillary light reflex (PLR). Health status was assessed using the General Health Questionnaire 28 (GHQ 28). PLR was recorded by alternating black (luminance 0.8 cd/m2) and white (luminance 100 cd/m2) screens for 3 seconds (5 times) to both eyes using a new pupil measuring device, KIKU-NAC (nac Image Technology). Subjects with a GHQ28 score of 6 or more had a significantly larger root mean squared error (RMSE) of maximum pupil diameter (p=0.004). There was also a positive correlation between the higher GHQ28 score and the increased RMSE (r=0.379, p=0.025). The PLR to alternating black and white stimuli can be used to assess physical and psychological symptoms.
