2025 Volume 62 Issue 2 Pages 43-48
Parkinson’s disease is a progressive disorder that, in addition to motor symptoms, is accompanied by autonomic dysfunction, which becomes more pronounced as the disease progresses. Circulatory abnormalities such as orthostatic hypotension, supine hypertension, and nocturnal blood pressure abnormalities are closely associated with the development of dementia and the progression of white matter lesions, significantly impairing patients’ quality of life and life prognosis. These abnormalities, influenced by both vascular factors and the progression of neurodegeneration, exert a substantial impact on the entire body and the central nervous system, underscoring the importance of early diagnosis and appropriate intervention. This article provides an overview of the pathophysiology, diagnostic methods, associated factors, and clinical significance of circulatory abnormalities in Parkinson’s disease, based on the latest findings, and discusses directions for management and therapeutic strategies.
