Evaluation of voriconazole oral dosage in Japan

Abstract

Voriconazole (VRCZ), a broad-spectrum triazole, is served in two dosage forms-injection and oral. VRCZ is difference dosage of oral and intravenous administration writing a medical package insert in Japan.

6mg/kg intravenous injection (IV) twice daily for the first day as initial loading dose, followed by 3-4mg/kg IV twice daily between meals is recommended. 300mg orally twice daily for first day as initial loading dose, followed by 150-200mg orally twice daily between meals is recommended. Patients weighing over 40kg, 200mg orally twice daily between meals is recommended. Patients weighing under 40kg, 100mg orally twice daily between meals is recommended, increase to 150mg twice daily if inadequate response. This study evaluated VRCZ through concentration and oral dosage in the 23 cases which administered VRCZ to analysis for TDM in Aichi University Hospital. Superman rank correlation coefficient was calcuated to examine relationships amoong variables. The level of statistical significance was set at p=0.05. All data were analyzed and processed on JMP^® 8 (SAS Institute Japan). There waws a significant positive correlation between VRCZ trough concentration and dose/weight (r=0.47 p＜0.05).

In this result, VRCZ oral dosage is appropriate to administer and dose/weight (mg/kg) twice a day as same as IV.