2020 Volume 73 Issue 4 Pages 115-129
Antimicrobial susceptibilities of 12 bacterial species isolated at Toyama University Hospital between 2018 and 2019 were measured. We calculated the target attainment rates for several dosing regimens of piperacillin (PIPC) against 12 bacterial species using monte carlo simulation with a view to examining the effect by increase in dose of PIPC.
Antimicrobial susceptibilities of methicillin-susceptible Staphylococcus aureus (MSSA), Streptococcus pneumoniae, Enterococcus faecalis, Klebsiella pneumoniae, Enterobacter cloacae, Moraxella catarrhalis and Pseudomonas aeruginosa of 12 bacterial species to PIPC were similar levels to those in nationwide surveillance in 2016 or 2018. On the other hand, antimicrobial susceptibilities of Escherichia coli and Serratia marcescens to PIPC were superior to those in nationwide surveillance.
In analysis using monte carlo simulation, the regimens of 2g four times daily, 4g three times daily and 4 g four times daily of PIPC were expected to show more excellent clinical efficacy than those of 2 g twice daily and 4 g twice daily of PIPC in terms of bacteriostatic effect and maximum bactericidal effect.
