A NEW ANTIBIOTIC, MACROMOMYCIN, EXHIBITING ANTITUMOR AND ANTIMICROBIAL ACTIVITY

HIDEO CHIMURA; MASAAKI ISHIZUKA; MASA HAMADA; SENJI HORI; KYOKO KIMURA; JUNKO IWANAGA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.21.44

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

A NEW ANTIBIOTIC, MACROMOMYCIN, EXHIBITING ANTITUMOR AND ANTIMICROBIAL ACTIVITY

HIDEO CHIMURA, MASAAKI ISHIZUKA, MASA HAMADA, SENJI HORI, KYOKO KIMURA, JUNKO IWANAGA, TOMIO TAKEUCHI, HAMAO UMEZAWA

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1968 Volume 21 Issue 1 Pages 44-49

DOI https://doi.org/10.7164/antibiotics.21.44

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Abstract

A macromolecular peptide was isolated from a culture filtrate of Streptomyces macromomyceticus n. sp. which is described in this paper. Macromomycin was isolated as a white powder by precipitation with ammonium sulfate, followed by dialysis, Dowex 1X2 column chromatography and Sephadex chromatography. It is a peptide with Sw20 value of 1.27 and a molecular weight of about 15, 000. It inhibits sarcoma 180 and mouse leukemia L-1210. It inhibits S. aureus, M. flavus, S. lutea, B. subtilis, and B. anthracis.

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