A NEW ANTIBIOTIC, 1-(p-HYDROXYPHENYL)-2, 3-DIISOCYANO-4-(p-METHOXYPHENYL)-BUTA-1, 3-DIENE. I

ISOLATION AND BIOLOGICAL PROPERTIES (STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. II)

Abstract

A new antibiotic, 1-(p-hydroxyphenyl)-2, 3-diisocyano-4-(p-methoxyphenyl)-buta-l, 3-diene, was isolated from the mycelium of Dichotomomyces albus Saito in crystalline form by utilizing the paper disc-agar diffusion plaque inhibition method. The antibiotic inhibits the plaque formation of Newcastle disease virus infected on primary chick embryo fibroblast cell monolayer. It is active against some gram-positive and gram-negative bacteria, including Shigella flexneri and Proteus vulgaris.