The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A NEW ANTIBIOTIC, 1-(p-HYDROXYPHENYL)-2, 3-DIISOCYANO-4-(p-METHOXYPHENYL)-BUTA-1, 3-DIENE. I
ISOLATION AND BIOLOGICAL PROPERTIES (STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. II)
KUNIO ANDOSEIKICHI SUZUKIAKIRA TAKATSUKIKEI ARIMAGAKUZO TAMURA
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1968 Volume 21 Issue 10 Pages 582-586

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Abstract

A new antibiotic, 1-(p-hydroxyphenyl)-2, 3-diisocyano-4-(p-methoxyphenyl)-buta-l, 3-diene, was isolated from the mycelium of Dichotomomyces albus Saito in crystalline form by utilizing the paper disc-agar diffusion plaque inhibition method. The antibiotic inhibits the plaque formation of Newcastle disease virus infected on primary chick embryo fibroblast cell monolayer. It is active against some gram-positive and gram-negative bacteria, including Shigella flexneri and Proteus vulgaris.

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© Japan Antibiotics Research Association
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