CHEMICAL STUDY OF FATTY ACIDS WITH ANTITUMOR ACTIVITY ISOLATED FROM FUNGAL MYCELIA

STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. VIII

Abstract

The isolation of antitumor active oily substances from the mycelia of Penicillium crustosum, Penicillium tardum, Cephalosporium diospyri and Sepedonium ampullosprum has been described previously. The present paper describes chemical studies on these active products. Their infrared absorption spectra were virtually identical and were typical of long-chain fatty acids.Nuclear magnetic resonance spectra confirmed the presence of long-chain methylene and methylene interrupted double bonds. Mass spectra and the gas chromatographic studies of the methyl esters indicated the presence of palmitic, octadecaenoic and octadecadienoic acids as major constituents.