STUDIES ON THE ANTIBIOTICS FROM STREPTOMYCES SPINICHROMOGENES VAR. KUJIMYCETICUS. II

ISOLATION AND CHARACTERIZATION OF KUJIMYCINS A AND B

Abstract

Two new antibiotics, kujimycins A and B, were isolated from the fermentation broth of Streptomyces sp. TPR-885 and purified by the extraction with ethyl acetate, gel filtration on Sephadex LH-20 and silica gel column chromatography. Kujimycin A was obtained as colorless powder, m. p. 114-115°C, C₄₀H₇₀O₁₅. Kujimycin B was obtained as colorless prisms, m.p. 178-180°C, C₄₂H₇₂O₁₆. They were suggested to be neutral macrolides which have antimicrobial activities against Gram-positive bacteria.