The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON CIRRAMYCIN A1. IV
DERIVATIVES OF CIRRAMYCIN A1
HIROSHI TSUKIURA, MASATAKA KONISHI, MIEKO SATA, KEI-ICHI FUJISAWA, TOMOO OHMORI, TOSHIO HOSHIYA, HIROSHI KAWAGUCHI
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1969 Volume 22 Issue 3 Pages 100-105

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Abstract

A variety of cirramycin derivatives has been prepared by modifying the hydroxyl groups, aldehyde function, dimethylamino group of mycaminose or the conjugated carbonyl system of the cirramycin A1 molecule. Among the derivatives evaluated, disuccinylcirramycin A1 (III) was found to possess some improved biological properties with respect to oral absorption, local tissue irritability as well as general toxicity.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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