METABOLISM OF CEPHALEXIN-¹⁴C IN MICE AND IN RATS

Abstract

The metabolic fate of the orally effective antibiotic, cephalexin, has been studied in the rat and the mouse. Cephalexin is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. Cephalexin is not metabolized in the body and is eliminated as unaltered antibiotic primarily via the urine. Cephalexin is more rapidly absorbed and eliminated by the mouse than by the rat.