The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
JANIEMYCIN, A NEW PEPTIDE ANTIBIOTIC
EDWARD MEYERSFRANK L. WEISENBORNFELIX E. PANSYDOROTHY S. SLUSARCHYKMALCOLM H. VON SALTZAMARLENE L. RATHNUMWILLIAM L. PARKER
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1970 Volume 23 Issue 10 Pages 502-507

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Abstract
Janiemycin is a new basic peptide antibiotic produced by a strain of Streptomyces macrosporeus ATCC 21, 388. It is a bactericidal compound, active primarily against gram-positive bacteria. In model murine infections with Streptococcus pyogenes C203 and Diplococcus pneumoniae Type 3, janiemycin is as active as penicillin G; moreover, a single subcutaneous dose provides prolonged protection (at least 48 hours) to mice infected with S. pyogenes C 203. Janiemycin and enduracidin are apparently related, but they are easily distinguished by the absence of α-amino-3, 5-dichloro-4-hydroxyphenylacetic acid from the hydrolysate of janiemycin.
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© Japan Antibiotics Research Association
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