ANTIBIOTIC 6640. II

FERMENTATION, ISOLATION, AND PROPERTIES

Abstract

Antibiotic 6640 is produced by aerobic submerged fermentation of a new species of organism, Micromonospora inyoensis (NRRL 3292). The antibiotic is produced substantially as a single component and is extracted from the broth by a cationic exchange procedure. It is purified by use of an anionic resin. Chromatographic studies indicate that it most nearly resembles, but is different from gentamicin C₁a. This report describes the production, isolation, , purification, and chemical and physical properties of antibiotic 6640.