LETHAL EFFECT OF BLEOMYCIN ON CULTURED MAMMALIAN CELLS

Abstract

By using cultured mammalian cells lethal effect of bleomycin was measured in terms of mean lethal dose (D₃₇) ; the cytotoxicity on proliferative system was moderate as compared with those of other anti-tumor agents ; the dose-response revealed marked difference between two mammalian cells used. The pattern of drug response during the cell cycle was demonstrated by virtue of the synchrony method. The similarity to the pattern of X-ray response strongly suggested the involvement of the same mechanism in lethal action of bleomycin.