Abstract
Mikamycins A & B containing mikamycin A as the main component and mikamycin B as the minor component were tritiated. The 3H-mikamycins A & B were administered orally to mice in four doses of 0.1, 1.0, 10.0 mg/kg/day (for 10 days) and 50 mg/kg (single dose). The amount of 3H-mikamycins A & B excreted into urine and feces was measured daily and totalled, and radioactivity remaining in the mice bodies was determined at intervals after administration ended. Thus, absorption, excretion and a material balance of mikamycins A & B were calculated. At every dose, more than 98% of the radioactivity recovered was excreted in urine and feces within one to several days after administration ended.
