A NEW PEPTIDE ANTIBIOTIC COMPLEX S-520. I

ISOLATION AND CHARACTERIZATION

Abstract

An antibiotic named S-520 was isolated from a strain S-520 which was identified as Streptomyces diastaticus. The antibiotic is primarily active against gram-positive bacteria. The antibiotic is suggested to be a complex which consists of several peptides closely related to each other. It has λ^MeOh_max : 227 mμ, 283.5 mμ, 290 mμ and 299.5 mμ and [α]_D +13.2°C (in methanol). Analytical data corresponds to C₄₀H_59-60O₁₀N_8-9Cl. Glycine, valine, isoleucine, ornithine, lysine and some unknown amino acids are produced on hydrolysis.