STUDIES ON ANTIBIOTIC SF-837, A NEW ANTIBIOTIC. I THE PRODUCING MICROORGANISM AND ISOLATION AND CHARACTERIZATION OF THE ANTIBIOTIC

TAKSHI TSURUOKA; TAKASHI SHOMURA; NORIO EZAKI; HIROSHI WATANABE; EIICHI AKITA; SHIGEHARU INOUYE; TATO NIIDA

doi:10.7164/antibiotics.24.452

STUDIES ON ANTIBIOTIC SF-837, A NEW ANTIBIOTIC. I

THE PRODUCING MICROORGANISM AND ISOLATION AND CHARACTERIZATION OF THE ANTIBIOTIC

TAKSHI TSURUOKA, TAKASHI SHOMURA, NORIO EZAKI, HIROSHI WATANABE, EIICHI AKITA, SHIGEHARU INOUYE, TATO NIIDA

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JOURNAL FREE ACCESS

1971 Volume 24 Issue 7 Pages 452-459

DOI https://doi.org/10.7164/antibiotics.24.452

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Abstract

A new antibiotic, SF-837, having potential utility as a chemotherapeutic agent was discovered in the culture broth of Streptomyces mycarofaciens SHOMURA and NIIDA nov. sp. Antibiotic SF-837 is a basic macrolide showing a UV maximum at 232 mμ, and is different from the leucomycins, josamycin, the spiramycins and the tertiomycins. It has a molecular formula C₄₁H₆₇NO₁₅ (MW, 813), and liberated 2 moles of propionic acid on hydrolysis.

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