BICYCLOMYCIN, A NEW ANTIBIOTIC

I. TAXONOMY, ISOLATION AND CHARACTERIZATION

Abstract

Bicyclomycin is a new antibiotic obtained from the culture filtrate of Streptomyces sp. WS 4545 which was identified as a new species and given the name Streptomyces sapporonensis. Its elementary analysis and mass spectroscopic measurement suggest that the molecular formula is C₁₂H₁₈N₂O₇. There is no specific ultraviolet absorption. Bicyclomycin is active against Gramnegative bacteria, especially Escherichia coli, Klebsiella, Shigella and Salmonella species, and has no cross resistance with the usual antibiotics. It has low toxicity in mice.