The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
DOPAMINE β-HYDROXYLASE INHIBITOR PRODUCED BY GLOEOPHYLLUM STRIATUM AND ITS IDENTITY WITH OOSPONOL
HAMAO UMEZAWA, HIRONOBU IINUMA, MANABU ITO, MEIKI MATSUZAKI, TOMIO TAKEUCHI, OSAMU TANABE
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1972 Volume 25 Issue 4 Pages 239-242

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Abstract

A dopamine β-hydroxylase inhibitor produced by Gloeophyllum striatum was isolated and found to be identical with oosponol. The inhibition is competitive with tyramine and noncompetitve with ascorbic acid. This inhibitor showed a hypotensive effect.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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