JOLIPEPTIN, A NEW PEPTIDE ANTIBIOTIC

I. ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS

Abstract

A new antibiotic, jolipeptin, was isolated from the cells of Bacillus polymyxa var. colistinus KOYAMA, a colistin-producing strain. Jolipeptin is a polypeptide antibiotic containing glycine, alanine, serine, valine, glutamic acid and α, γ-diaminobutyric acid. It contains no fatty acids as does colistin. It inhibits growth of gram-positive and gram-negative bacteria.