EM49, A NEW PEPTIDE ANTIBIOTIC I. FERMENTATION, ISOLATION, AND PRELIMINARY CHARACTERIZATION

EDWARD MEYERS; WILLIAM E. BROWN; PACIFICO A. PRINCIPE; MARLENE L. RATHNUM; WILLIAM L. PARKER

doi:10.7164/antibiotics.26.444

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

EM49, A NEW PEPTIDE ANTIBIOTIC

I. FERMENTATION, ISOLATION, AND PRELIMINARY CHARACTERIZATION

EDWARD MEYERS, WILLIAM E. BROWN, PACIFICO A. PRINCIPE, MARLENE L. RATHNUM, WILLIAM L. PARKER

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JOURNAL FREE ACCESS

1973 Volume 26 Issue 8 Pages 444-448

DOI https://doi.org/10.7164/antibiotics.26.444

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Abstract

EM 49 is a new basic peptide antibiotic complex produced by a strain of Bacillus circulans. When isolated as the hydrochloride, it has an approximate empirical formula of C_49-50H_91-98N₁₃O₁₀Cl₄. The antibiotic has broad-spectrum antibacterial activity and also displays considerable antifungal and antiprotozoal activities. EM 49 is not cross-resistant with other antibiotics, including those of a peptide nature.

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