AMINOGLYCOSIDE ANTIBIOTICS. IX STRUCTURE-ACTIVITY RELATIONSHIP IN 1-N-ACYL DERIVATIVES OF KANAMYCIN A (AMIKACIN ANALOGS)

TAKAYUKI NAITO; SUSUMU NAKAGAWA; YUKIO NARITA; SOICHIRO TODA; YOSHIO ABE; MASAHISA OKA; HARUHIRO YAMASHITA; TETSURO YAMASAKI; KEI-ICHI FUJISAWA; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.27.851

AMINOGLYCOSIDE ANTIBIOTICS. IX

STRUCTURE-ACTIVITY RELATIONSHIP IN 1-N-ACYL DERIVATIVES OF KANAMYCIN A (AMIKACIN ANALOGS)

TAKAYUKI NAITO, SUSUMU NAKAGAWA, YUKIO NARITA, SOICHIRO TODA, YOSHIO ABE, MASAHISA OKA, HARUHIRO YAMASHITA, TETSURO YAMASAKI, KEI-ICHI FUJISAWA, HIROSHI KAWAGUCHI

Author information

TAKAYUKI NAITO
Bristol-Banyu Research Institute, Ltd.
SUSUMU NAKAGAWA
Bristol-Banyu Research Institute, Ltd.
YUKIO NARITA
Bristol-Banyu Research Institute, Ltd.
SOICHIRO TODA
Bristol-Banyu Research Institute, Ltd.
YOSHIO ABE
Bristol-Banyu Research Institute, Ltd.
MASAHISA OKA
Bristol-Banyu Research Institute, Ltd.
HARUHIRO YAMASHITA
Bristol-Banyu Research Institute, Ltd.
TETSURO YAMASAKI
Bristol-Banyu Research Institute, Ltd.
KEI-ICHI FUJISAWA
Bristol-Banyu Research Institute, Ltd.
HIROSHI KAWAGUCHI
Bristol-Banyu Research Institute, Ltd.

JOURNAL FREE ACCESS

1974 Volume 27 Issue 11 Pages 851-858

DOI https://doi.org/10.7164/antibiotics.27.851

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Abstract

Twenty-three 1-N-acyl derivatives of kanamycin A were prepared and their in vitro activities against kanamycin-sensitive and resistant organisms were compared with amikacin.

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