STUDIES ON THE MACROLIDE ANTIBIOTIC YL-704 COMPLEX. II

ISOLATION AND PHYSICOCHEMICAL PROPERTIES OF YL-704 COMPONENTS

Abstract

New family of the basic macrolide antibiotics, numbered YL-704, was isolatedfrom the culture broth of Streptomyces platensis subsp. malvinus MCRL 0388. YL-704 family was constituted of at least thirteen components which were classified into the three types according to their UV absorption pattern; first type (YL-704 W₁ and W₂) with the absorption maximum at 280 nm as carbomycin B, second type (YL-704 A₁, A₀, A₂, A₃, B₁, B₂, B₃ and C₂) with the maiximum at 232 nm as leucomycins, and third type (YL-704 C₁, C₃ and C₄) with no characteristic UV absorption.