The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
RAPAMYCIN (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC
II. FERMENTATION, ISOLATION AND CHARACTERIZATION
S. N. SEHGALH. BAKERClaude VÉZINA
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1975 Volume 28 Issue 10 Pages 727-732

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Abstract

Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183-185°C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.

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