1975 Volume 28 Issue 4 Pages 253-259
Lipiarmycin, a metabolite of Actinoplanes deccanensis nov. sp. (PARENTI et al.), has been isolated in pure form. It has a molecular formula C52-54H74-76Cl2O19, (M.W.=1, 073-1, 099). From its chemical and physico-chemical characteristics, lipiarmycin can be considered a new antibiotic. Lipiarmycin is highly active against Gram-positive bacteria, including strains resistant to the medically important antibiotics and protects mice experimentally infected with Streptococcus haemolyticus. Lipiarmycin inhibits growth of susceptible bacteria by interfering with RNA synthesis.