The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
LIPIARMYCIN, A NEW ANTIBIOTIC FROM ACTINOPLANES
II. ISOLATION, CHEMICAL, BIOLOGICAL AND BIOCHEMICAL CHARACTERIZATION
C. CORONELLIR. J. WHITEG. C. LANCINIF. PARENTI
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1975 Volume 28 Issue 4 Pages 253-259

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Abstract

Lipiarmycin, a metabolite of Actinoplanes deccanensis nov. sp. (PARENTI et al.), has been isolated in pure form. It has a molecular formula C52-54H74-76Cl2O19, (M.W.=1, 073-1, 099). From its chemical and physico-chemical characteristics, lipiarmycin can be considered a new antibiotic. Lipiarmycin is highly active against Gram-positive bacteria, including strains resistant to the medically important antibiotics and protects mice experimentally infected with Streptococcus haemolyticus. Lipiarmycin inhibits growth of susceptible bacteria by interfering with RNA synthesis.

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