STREPTOVIRUDINS, NEW ANTIBIOTICS WITH ANTIBACTERIAL AND ANTIVIRAL ACTIVITY

II. ISOLATION, CHEMICAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF STREPTOVIRUDINS A₁, A₂, B₁, B₂, C₁, C₂, D₁ AND D₂

Abstract

Streptovirudin is a complex of antibiotics isolated from fermentation of a Streptomyces strain. Eight components have been isolated as pure substances, designated as streptovirudins A₁, A₂, B₁, B₂, C₁, C₂, D₁ and D₂. The streptovirudins are chemically and biologically related to each other and appear to be a new family of antibiotics exhibiting activity against a variety of Gram-positive bacteria, mycobacteria, and various DNA- and RNA-viruses. According to their physico-chemical properties these antibiotics have been classified in series I and II. The streptovirudins of series II (A₂, B₂, C₂, D₂) are related to the reported antibiotics tunicamycin, mycospocidin and 24010.