ISOLATION OF BREVISTIN, A NEW PEPTIDE ANTIBIOTIC

STUDIES ON ANTIBIOTICS FROM THE GENUS BACILLUS. IX

Abstract

A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C₆₃H₉₁N₁₅O₁₈ containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2, 4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol. Brevistin is active against Ggam-positive bacteria in vitro and in vivo, and is of low toxicity to mice.