NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC I. DISCOVERY, ISOLATION AND CHARACTERIZATION

HATSUO AOKI; HEI-ICHI SAKAI; MASANOBU KOHSAKA; TOSHIO KONOMI; JUNJI HOSODA; YOSHIAKI KUBOCHI; EIKO IGUCHI; HIROSHI IMANAKA

doi:10.7164/antibiotics.29.492

NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC

I. DISCOVERY, ISOLATION AND CHARACTERIZATION

HATSUO AOKI, HEI-ICHI SAKAI, MASANOBU KOHSAKA, TOSHIO KONOMI, JUNJI HOSODA, YOSHIAKI KUBOCHI, EIKO IGUCHI, HIROSHI IMANAKA

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JOURNAL FREE ACCESS

1976 Volume 29 Issue 5 Pages 492-500

DOI https://doi.org/10.7164/antibiotics.29.492

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Abstract

Nocardicin A is a new monocyclic β-lactam antibiotic obtained from the fermentation broth of a strain of actinomycetes. The producing organism, strain WS 1571, was identified as Nocardia uniformis subsp.tsuyamanensis ATCC 21806. The antibiotic, obtained as colorless crystals, exhibits moderate in vitro antibacterial activity against a broad-spectrum of Gram-negative bacteria including Proteus and Pseudomonas. It has low toxicity in laboratory animals.

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