A NEW SEMISYNTHETIC 7α-METHOXYCEPHALOSPORIN, CS-1170: 7β-[[(CYANOMETHYL)THIO]ACETAMIDO]-7α-METHOXY-3-[[(1-METHYL-1H-TETRAZOL-5-YL)THIO]METHYL]-3-CEPHEM-4-CARBOXYLIC ACID

HIDEO NAKAO; HIROAKI YANAGISAWA; BUNJI SHIMIZU; MASAKATSU KANEKO; MITSUO NAGANO; SHINICHI SUGAWARA

doi:10.7164/antibiotics.29.554

HIDEO NAKAO, HIROAKI YANAGISAWA, BUNJI SHIMIZU, MASAKATSU KANEKO, MITSUO NAGANO, SHINICHI SUGAWARA

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JOURNAL FREE ACCESS

1976 Volume 29 Issue 5 Pages 554-558

DOI https://doi.org/10.7164/antibiotics.29.554

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Abstract

The synthesis and antimicrobial activity of a new semisynthetic 7α-methoxycephalosporin, 7β-[[(cyanomethyl)thio]acetamido]-7α -methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]- methyl]-3-cephem-4-carboxyacliicd (CS-1170), are described. This compound shows interesting antibacterial activity when compared to cefoxitin and cephalothin.

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