STRUCTURAL INVESTIGATION OF THE ANTIBIOTIC RISTOMYCIN A

SYNTHESIS OF RISTOBIOSE AND RISTOTRIOSE

Abstract

Proof is given by synthesis confirming the structure of ristobiose as 2-O-α-D-mannopyranosyl-D-glucose (IV) and ristotriose as O-α-L-rhamnopyranosyl (1→6)-O-[α-D-mannopyranosyl (1→2)]-D-glucose (X) which are obtained from ristomycin A upon mild acid hydrolysis. Both oligosaccharides, IV and X, have been detected for the first time as the components of an antibiotic.