CGP 9000: A NEW ORALLY ACTIVE, BROAD-SPECTRUM CEPHALOSPORIN

O. ZAK; W. A. VISCHER; C. SCHENK; W. TOSCH; W. ZIMMERMANN; J. REGÖS; E. R. SUTER; F. KRADOLFER; J. GELZER

doi:10.7164/antibiotics.29.653

O. ZAK, W. A. VISCHER, C. SCHENK, W. TOSCH, W. ZIMMERMANN, J. REGÖS, E. R. SUTER, F. KRADOLFER, J. GELZER

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JOURNAL FREE ACCESS

1976 Volume 29 Issue 6 Pages 653-655

DOI https://doi.org/10.7164/antibiotics.29.653

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Abstract

CGP 9000, (7-[D-2-amino-2-(1, 4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-
carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity
in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine.
Upon oral administration to mice infected with various bacteria, CGP 9000 is, in
general, 2 to 7 times more effective than either cephalexin or cephradine.

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