CGP 9000: A NEW ORALLY ACTIVE, BROAD-SPECTRUM CEPHALOSPORIN

O. ZAK; W. A. VISCHER; C. SCHENK; W. TOSCH; W. ZIMMERMANN; J. REGÖS; E. R. SUTER; F. KRADOLFER; J. GELZER

doi:10.7164/antibiotics.29.653

O. ZAK, W. A. VISCHER, C. SCHENK, W. TOSCH, W. ZIMMERMANN, J. REGÖS, E. R. SUTER, F. KRADOLFER, J. GELZER

Author information

O. ZAK
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
W. A. VISCHER
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
C. SCHENK
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
W. TOSCH
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
W. ZIMMERMANN
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
J. REGÖS
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
E. R. SUTER
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
F. KRADOLFER
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.
J. GELZER
Research Laboratories, Pharmaceuticals Division, CIBA-GELGY Ltd.

JOURNAL FREE ACCESS

1976 Volume 29 Issue 6 Pages 653-655

DOI https://doi.org/10.7164/antibiotics.29.653

Details

Abstract

CGP 9000, (7-[D-2-amino-2-(1, 4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-
carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity
in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine.
Upon oral administration to mice infected with various bacteria, CGP 9000 is, in
general, 2 to 7 times more effective than either cephalexin or cephradine.

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