The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
THE STROBILURINS -NEW ANTIFUNGAL ANTIBIOTICS FROM THE BASIDIOMYCETE STROBILURUS TENACELLUS (PERS. ex FR.) SING
T. ANKEF. OBERWINKLERW. STEGLICHG. SCHRAMM
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1977 Volume 30 Issue 10 Pages 806-810

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Abstract

The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Strobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the ascitic
form of EHRLICH carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are C16H18O3 for strobilurin A and C17H19ClO4 for strobilurin B.

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