STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XI

THE ARTIFACTS AND THE DEGRADATION PRODUCTS OF LYSOCELLIN

Abstract

Lysocellin is a new polyether antibiotic produced by Streptomyces cacaoi var. asoensis and is characterized as a broad spectrum ionophore having a higher complexation affinity for divalent cations than for monovalents and also having an ability to transport biological amines.
The structures of two artifacts designated L₁ and M₁ have been elucidated based on spectral evidence, and the formation mechanism of these compounds was discussed with respect to the reactivity of the antibiotic. In addition, a number of degradation and modified products were prepared in order to examine their biological activity and to utilize as the model compounds for ¹³C-NMR assignment.