THE DETERMINATION OF CEPHRADINE AND CEPHALEXIN BY REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

MARGARET A. CARROLL; E. RODERICK WHITE; ZSUZSA JANCSIK; JOHN E. ZAREMBO

doi:10.7164/antibiotics.30.397

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

THE DETERMINATION OF CEPHRADINE AND CEPHALEXIN BY REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

MARGARET A. CARROLL, E. RODERICK WHITE, ZSUZSA JANCSIK, JOHN E. ZAREMBO

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1977 Volume 30 Issue 5 Pages 397-403

DOI https://doi.org/10.7164/antibiotics.30.397

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Abstract

The application of reverse phase high-performance liquid chromatography to the separation and analysis of cephradine and cephalexin is demonstrated. The procedure has been applied to chemicals, pharmaceutical formulations and reaction solutions. The preparation of samples is simple and rapid. Chromatographic conditions are described for both pellicular and small particle columns. The feasibility of determining cephradine and cephalexin in physiological fluids has also been demonstrated.

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