MACROLIDE ANTIBIOTICS M-4365 PRODUCED BY MICROMONOSPORA I. TAXONOMY, PRODUCTION, ISOLATION, CHARACTERIZATION AND PROPERTIES

TAMOTSU FURUMAI; ISAO MAEZAWA; NOBUO MATSUZAWA; SHIGERU YANO; TOTARO YAMAGUCHI; KATSUO TAKEDA; TOMOHARU OKUDA

doi:10.7164/antibiotics.30.443

MACROLIDE ANTIBIOTICS M-4365 PRODUCED BY MICROMONOSPORA

I. TAXONOMY, PRODUCTION, ISOLATION, CHARACTERIZATION AND PROPERTIES

TAMOTSU FURUMAI, ISAO MAEZAWA, NOBUO MATSUZAWA, SHIGERU YANO, TOTARO YAMAGUCHI, KATSUO TAKEDA, TOMOHARU OKUDA

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JOURNAL FREE ACCESS

1977 Volume 30 Issue 6 Pages 443-449

DOI https://doi.org/10.7164/antibiotics.30.443

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Abstract

A series of basic 16-membered macrolide antibiotics, M-4365 A₁, A₂, A₃, G₁, G₂ and G₃, were isolated from the culture broth of strain MCRL 0940 which is assigned to be a new species of Micromonospora and for which the name Micromonospora capillata sp. nov. is proposed. Among these antibiotics, M-4365 A₂ and G₂ showed strong inhibitory activity against Grampositive and Gram-negative bacteria.

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