A NEW ANTIBIOTIC, SETOMIMYCIN, PRODUCED BY A STRAIN OF STREPTOMYCES

SATOSHI OMURA; HARUO TANAKA; YUZURU IWAI; KAZUE NISHIGAKI; JUICHI AWAYA; YOKO TAKAHASHI; ROKUROU MASUMA

doi:10.7164/antibiotics.31.1091

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

A NEW ANTIBIOTIC, SETOMIMYCIN, PRODUCED BY A STRAIN OF STREPTOMYCES

SATOSHI OMURA, HARUO TANAKA, YUZURU IWAI, KAZUE NISHIGAKI, JUICHI AWAYA, YOKO TAKAHASHI, ROKUROU MASUMA

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JOURNAL FREE ACCESS

1978 Volume 31 Issue 11 Pages 1091-1098

DOI https://doi.org/10.7164/antibiotics.31.1091

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Abstract

A new antibiotic, setomimycin, was isolated from the culture broth of strain AM-2947, which was identified as Streptomyces pseudovenezuelae. The compound is a weakly acidic substance, and has UV-absorptions at 228, 268 and 422 nm and a molecular formula of C₃₄H₂₈O₉(MW 580). It is active against Gram-positive bacteria including Mycobacteria, and has antitumor activity against Sarcoma-180 solid tumor in mice.

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