CLAVULANIC ACID INHIBITION OF β-LACTAMASE I FROM BACILLUS CEREUS 569/H

JON P. DURKIN; THAMMIAH VISWANATHA

doi:10.7164/antibiotics.31.1162

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

CLAVULANIC ACID INHIBITION OF β-LACTAMASE I FROM BACILLUS CEREUS 569/H

JON P. DURKIN, THAMMIAH VISWANATHA

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JOURNAL FREE ACCESS

1978 Volume 31 Issue 11 Pages 1162-1169

DOI https://doi.org/10.7164/antibiotics.31.1162

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Abstract

Inactivation of β-lactamase I by clavulanic acid was investigated. Clavulanic acid induced inhibition of the enzyme was found to be progressive with time. Benzylpenicillin provided protection against the adverse effects of the inhibitor initially, however, the enzyme was irreversibly inhibited in a progressive manner even in the presence of substrate. Reaction of β-lactamase I with clavulanic acid, in the presence of ampicillin, led to a very rapid inactivation of the enzyme.

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