FUNICULOSIN, A NEW ANTIBIOTIC II. STRUCTURE ELUCIDATION AND ANTIFUNGAL ACTIVITY

KUNIO ANDO; IKUTOSHI MATSUURA; YOSHIHARU NAWATA; HISAO ENDO; HIROSHI SASAKI; TSUNEO OKYTOMI; TETSUJI SAEHI; GAKUZO TAMURA

doi:10.7164/antibiotics.31.533

FUNICULOSIN, A NEW ANTIBIOTIC

II. STRUCTURE ELUCIDATION AND ANTIFUNGAL ACTIVITY

KUNIO ANDO, IKUTOSHI MATSUURA, YOSHIHARU NAWATA, HISAO ENDO, HIROSHI SASAKI, TSUNEO OKYTOMI, TETSUJI SAEHI, GAKUZO TAMURA

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JOURNAL FREE ACCESS

1978 Volume 31 Issue 6 Pages 533-538

DOI https://doi.org/10.7164/antibiotics.31.533

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Abstract

Structure elucidation and some biological properties of an antiviral and antifungal antibiotic, funiculosin, are summarized. Funiculosin is a derivative of N-methyl-4-hydroxy-3, 5- disubstituted-2-pyridone containing a novel substituent, cyclopentanetetrol moiety, that is reported here for the first time in a natural product. The antibiotic protects guinea pigs efficiently against experimental trichophytosis. Toxicity of funiculosin is unique and highly selective for animal species.

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