ISOLATION OF EKATETRONE, A NEW METABOLITE OF PRODUCING VARIANTS OF STREPTOMYCES AUREOFACIENS

Abstract

From a mixture of substances formed by producing strains of Streptomyces aureofaciens under conditions of submerged fermentation a new metabolite, ekatetrone, was isolated. Its isolation and basic physical and chemical data are described. Ekatetrone is a quinone derivative with a carboxamide group. In tests in vitro with cells of EHRLICH's ascites tumour evidence was provided that ekatetrone inhibits proteo- and nucleosynthesis.